The Colombo Plan releases timely public health alerts as part of a broader effort to raise the alarm on newly, emerging lethal synthetic drugs, complex drug mixtures, unknown substances, and dangerous drug/toxic adulterant combinations in the global drug supply, in collaboration with the Center for Forensic Science Research and Education (CFSRE). These alerts are designed to raise awareness about the dynamic composition and dangers of substances proliferating the illicit market, help mitigate harm to users and improve public health interventions. By providing crucial information to communities, The Colombo Plan aims to ensure that individuals and organisations are equipped to respond to these health risks and promote safer environments worldwide.